Transaminase of Brain (II)
نویسندگان
چکیده
منابع مشابه
Effect of hydroxymethylpyrimidine on brain transaminase and glutamic decarboxylase.
It has been shown that 4-desoxypyridoxine (1, 2), incites seizures (3) and vita min B6-deficient states (3-6) in animals, but INAH (1) also has the property of inducing running fits (7, 8, 9) and vitamin B6 deficiency (10-13) and of inhibiting the enzymes related to vitamin B6 (14-20). The results of Makino and Aramaki (21-25), Kooka (26) and Miyake (27) show that 2-methyl-4-amino5-hydroxymethy...
متن کاملEffects of Vitamin B6 on the Brain Glutamate Pyrovate Transaminase and Glutamate Oxaloacetate Transaminase in Young and Old Rats
Excessive amounts of extracellular glutamate in brain are excitotoxic and lead to neuronal death. Glutamate pyrovate transamiase (GPT) and glutamate oxaloacetate transaminase (GOT) catalyze transamination of glutamate to alpha ketoglutarate. Because vitamin B6 is essential for the enzymes activities, this study was undertaken to examine the effect of vitamin B6 on age related changes of this en...
متن کاملEffects of administration of estrogens upon enzymes of rat pituitary. II. Aconitase, succinoxidase, and transaminase.
Succinoxidase, aconitase, and glutamic-oxalacetic transalninase have been studied in the pituitary and liver of male rats during the induction of pituitary tumors by treatment with diethylstilbestrol. In the pituitary the two rcpresentatives of the tricarboxylic acid cycle were decreased by approximately the same amount. The changes in these enzymes occurred soon after the beginning of the trea...
متن کاملGlutamic Aspartic Transaminase
Aspartate and glutamate react instantaneously with the pyridoxal form of the pig heart glutamic aspartic transaminase (1) to yield the corresponding keto acid, converting the enzymebound pyridoxal phosphate to bound pyridoxamine phosphate (2). Other amino acids such as methionine sulfoxide, methionine sulfone, and alanine react much more slowly with the enzyme, but the reaction itself appears t...
متن کاملGlutamic aspartic transaminase. II. The influence of pH on absorption spectrum and enzymatic activity.
Isotopes have been used to study transaminases in several ways. Substrates labeled with N15 were used to confirm the fact that transfer occurs between amino acid and keto acid without the formation of ammonia (1, 2), and without any requirement for a specific amino acid such as glutamate (3, 4). Experiments in deuterated water show that the a-hydrogen of the amino acid is liberated as a hydroge...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1960
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.72.2_515